Table 5.

Alternative cut-off values for the TDI-E.

Cut-off	Youden	Sensitivity	95% CI	Specificity	95% CI	+LR	95% CI	−LR	95% CI	+PV	95% CI	−PV	95% CI
>6	0.204	95.4	88.6–98.7	24.97	21.9–28.2	1.27	1.2–1.4	0.18	0.07–0.5	12.9	12.2–13.6	97.9	94.7–99.2
>11	0.441	90.8	82.7–95.9	53.27	49.6–56.9	1.94	1.8–2.2	0.17	0.09–0.3	18.4	16.9–20.0	98	96.3–99.0
>13	0.471	82.76	73.2–90.0	64.35	60.8–67.8	2.32	2.0–2.7	0.27	0.2–0.4	21.2	19.1–23,6	97	95.3–98.1
>18	0.544	68.97	58.1–78.5	85.45	82.7–87.9	4.74	3.8–5.9	0.36	0.3–0.5	35.5	30.6–40.8	96	94.5–97.0
>20	0.518	62.07	51.0–72.3	89.72	87.3–91.8	6.04	4.6–7.9	0.42	0.3–0.6	41.2	34.9–47.8	95.3	94.0–96.4
>23	0.387	43.68	33.1–54.7	95.06	93.3–96.5	8.84	6.0–13.1	0.59	0.5–0.7	50.7	40.9–60.4	93.6	92.3–94.6
>25	0.267	28.74	19.5–39.4	98.00	96.7–98.9	14.35	7.9–26.2	0.73	0.6–0.8	62.5	47.8–75.2	92.2	91.2–93.1

In bold, the recommended cut-off value.

+LR, positive likelihood ratio; −LR, negative likelihood ratio; +PV, positive predictive values; −PV, negative predictive values.