TABLE 1.

A brief history of mechanobiology of the N-methyl-D-aspartate receptor (NMDAR).

Year	First author	Last author	Inst location	Journal	Cell type/Body region	IV	DV	Summary
1992	Miller	Atwell	U London	Nature	Cerebellar granule	AA	Currents	AA potentiates currents
1994	Paoletti	Ascher	Ecole N Sup Paris	Neuron	Mouse cultured neurons	Osmolarity and Stretch	Currents	NMDA current increase -reduce osmolarity
1998	Casado	Ascher	Ecole N Sup Paris	J Physiol	Cortical cultures	Lysophosphlipids and AA	Currents	AA potentiates currents
2004	Chaban	McRoberts	UCLA	Neuroscience	DRG	Poke glass pippettes	Ca2+ Imaging	Poke increase Ca2+ imaging
2007a	Kloda	Martinac	U Queensland	PNAS	Artificial bilayer	Stretch and AA	Currents	AA and Stretch potentiate NMDAR currents
2008	Ma	Lee	Fu Jen Cath U	Hypertension	Renal afferent nerve	Endogenous pressure	Urine output	NMDAzeta1 found in Renal Nerve
2009	Parnas	Minke	Hebrew U	J Neurosci	Photo R and CAI	Linoleic acid (LA)	Currents	Lipid mod removes Open Channel Block
2012	Singh	Meaney	U Penn	J Biol Chem	HEK 293	Stretch	Ca2+ Imaging	Stretch sensitivity C term Ser-1323 NR2B
2017	Maneshi	Hua	SUNY Buffalo	Sci Rep	Astrocytes rat	Shear stress	Ca2+ Imaging	Shear Stress - blocked by MK801

Chronology of publications reporting activation of NMDA receptor channels by physical and chemical stimuli that supported the notion of modulation of inherent mechanosensitivity of the channel and modulation of its activity by force from lipids (Note Miller et al., 1992, is included in table as the data has been retrospectively interpreted as relating to force from lipids mechanosensitivity). IV (independent variable), DV (dependent variable).