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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Pediatr Allergy Immunol. 2019 Jul 18;30(8):848–851. doi: 10.1111/pai.13101

Figure 1. Association of respiratory syncytial virus (RSV)-only and rhinovirus (RV)-only bronchiolitis with serum metabolomic profile.

Figure 1.

Data based on serum metabolites among infants with RSV-only (n=79) compared to those with RV-only (n=37) infection.

(A) Orthogonal partial least squares–discriminatory analysis (OPLS-DA) score scatter plot. Each dot is the representation of the serum metabolomic profile of a single infant in a two-dimensional space. The ellipses represent the 95% confidence interval. The overall serum metabolomic profiles of infants with RSV-only and that of RV-only clustered distinctly (P=0.006 with 2000 random permutations).

(B) Unsupervised hierarchical clustering of the 20 most significant metabolites using Euclidean distance with Ward linkage. Infants are shown in columns. Metabolites are shown in rows with the color representing the log-transformed intensity of metabolites, where blue is low and red is high. The row dendrogram is colored according to the metabolite being increased in RSV-only (red) or RV-only (green) and metabolite names are colored according to their super-pathway.