Table 1.
List of genes that are down-regulated in the absence of TRRAP and identified from our bioinformatic analyses.
| Gene Symbol | Entrez gene name | RNA-seq sgTRRAP/sgNT | GSE14520 HCC/non-tumor tissue | TCGA HCC co-expressed with TRRAP | |||
|---|---|---|---|---|---|---|---|
| Fold change | P-value | Fold change | P-value | Spearman’s coefficient | P-value | ||
| ASPM | Abnormal spindle microtubule assembly | 0.46 | 1.8E-02 | 8.22 | 8.3E-112 | 0.357 | 1.7E-11 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.42 | 2.6E-07 | 3.33 | 1.4E-73 | 0.428 | 2.0E-16 |
| CCNA2 | Cyclin A2 | 0.35 | 2.2E-03 | 2.45 | 1.7E-59 | 0.309 | 9.8E-09 |
| CENPF | Centromere protein F | 0.39 | 5.7E-03 | 5.25 | 3.9E-101 | 0.452 | 2.3E-18 |
| DBF4 | DBF4 zinc finger | 0.46 | 8.4E-06 | 2.41 | 2.6E-71 | 0.48 | 7.2E-21 |
| DLGAP5 | DLG associated protein 5 | 0.42 | 2.9E-06 | 2.49 | 6.9E-60 | 0.316 | 3.9E-09 |
| EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.38 | 5.5E-07 | 3.41 | 2.4E-78 | 0.408 | 6.1E-15 |
| FOXM1 | Forkhead box M1 | 0.38 | 4.5E-08 | 2.27 | 5.9E-67 | 0.414 | 2.2E-15 |
| KIF20A | Kinesin family member 20A | 0.23 | 1.2E-04 | 3.24 | 3.8E-80 | 0.332 | 5.9E-10 |
| KIF4A | Kinesin family member 4A | 0.41 | 5.5E-06 | 2.70 | 1.4E-69 | 0.314 | 5.3E-09 |
| MAD2L1 | Mitotic arrest deficient 2 like 1 | 0.45 | 1.2E-06 | 2.88 | 4.9E-62 | 0.321 | 2.3E-09 |
| MCM2 | Minichromosome maintenance complex component 2 | 0.38 | 1.9E-07 | 3.13 | 6.3E-69 | 0.342 | 1.5E-10 |
| MCM4 | Minichromosome maintenance complex component 4 | 0.46 | 1.0E-06 | 3.03 | 3.2E-72 | 0.53 | 5.9E-26 |
| MKI67 | Marker of proliferation ki-67 | 0.41 | 4.3E-02 | 2.38 | 9.5E-51 | 0.403 | 1.6E-14 |
| NSD2 | Nuclear receptor binding SET domain protein 2 | 0.46 | 3.5E-06 | 2.10 | 3.0E-61 | 0.605 | 2.6E-35 |
| PRC1 | Protein regulator of cytokinesis 1 | 0.40 | 4.9E-09 | 5.49 | 9.2E-106 | 0.378 | 8.2E-13 |
| RACGAP1 | Rac gtpase activating protein 1 | 0.39 | 1.2E-07 | 4.66 | 2.5E-108 | 0.333 | 5.1E-10 |
| RAD51AP1 | RAD51 associated protein 1 | 0.50 | 3.3E-04 | 2.59 | 2.0E-62 | 0.411 | 4.1E-15 |
| TOP2A | DNA topoisomerase II alpha | 0.34 | 5.2E-03 | 8.27 | 8.5E-98 | 0.406 | 8.6E-15 |
| TPX2 | TPX2, microtubule nucleation factor | 0.37 | 5.6E-08 | 3.22 | 7.3E-71 | 0.317 | 3.6E-09 |
| TTK | TTK protein kinase | 0.47 | 2.0E-05 | 3.22 | 9.7E-69 | 0.306 | 1.4E-08 |
| XPOT | Exportin for trna | 0.47 | 1.5E-08 | 2.44 | 1.9E-62 | 0.485 | 2.5E-21 |