Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 11;9:18795. doi: 10.1038/s41598-019-55455-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

ERBB2 amplicon structure is different in patient with localized and advanced disease. FAST analysis of low coverage whole genome sequencing (lcWGS) of two primary breast ER+/HER2+ tumors is visualized using Circus. The external ring represents chromosomal location; the inner ring shows areas of amplification as blue bars. Colored lines represent structural variations (SV), all the SV in an amplicon are colored with the same color. Although both (P-29 and P-13) are primary breast ER+/HER2+ tumors, P-29 was resected from a patient suffering from a metastatic disease as a palliative measure and P-13 was resected from a patient with a localized disease with curative intent. In P-29 the ERBB2 amplicon is composed of several segments (Panel A) and in P-13 of a single segment (Panel B). The ERBB2 amplicon is composed of a single segment, colored blue, in 17/19 patients with localized tumors, and is composed of multiple segments, colored red, in 8/9 patients with advanced tumors, Fisher exact test, two sided p = 0.0001 (Panel C).