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. 2019 Dec 11;9:18795. doi: 10.1038/s41598-019-55455-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Difference in ERBB2 amplicon in two breast tumors from the same patient. FAST analysis of low coverage whole genome sequencing (lcWGS) of two primary ER+/HER2+ and ER?/HER2+ breast tumors is visualized using Circus. The external ring represents chromosomal location on chromosome 17, the inner ring shows areas of amplification as blue bars. Colored lines represent structural variations (SV). Both tumors (P-102 and P-103) are primary HER2+ breast cancer. In P-102 the ERBB2 amplicon spans chr17:37,125,000-38,715,000, has eight copies and has an inverted duplication amplicon structure (panel A) while In P-103 the ERBB2 amplicon spans chr17:36,960,000-38,070,000, has 16 copies and has a double minute amplicon structure (panel B).