Table 1.

Spearman correlations of 23 in-clinic biosensor and structured testing measures with EDSS, MSFC-4, and MSFC-4 composite z-scores as observed at the second clinic visit (the first and third visits are summarized in the supplementary information).

Category	Feature	N	EDSS	MSFC-4 z-score	25 foot walk z-score	9-hole peg test z-score	Symbol-digit modality test z-score	LCVA test z-score
Mobility (gait)	Stance time	23	0.677**	−0.546**	−0.618**	−0.440*	−0.316	−0.447
	Swing time	23	0.469*	−0.425*	−0.484*	−0.380	−0.282	−0.451
	Mobility activity time	23	0.814**	−0.859**	−0.893**	−0.702**	−0.740**	−0.575
Mobility (turn)	Turn angle—chest	23	−0.444*	0.437*	0.442*	0.528*	0.400	0.230
	Turn duration—chest	23	0.021	0.125	0.150	0.286	0.148	0.026
	Turn velocity (max)—chest	23	−0.583*	0.653**	0.552*	0.597**	0.642**	0.456
	Turn velocity (mean)—chest	23	−0.563*	0.473*	0.382	0.436*	0.393	0.292
	Turn velocity (std)—chest	23	−0.588*	0.579**	0.476*	0.546**	0.618**	0.433
	Turn angle—ankle	23	−0.352	0.256	0.276	0.295	0.444*	−0.083
	Turn duration—ankle	23	0.004	−0.189	−0.140	−0.059	−0.028	−0.535
	Turn velocity (max)—ankle	23	−0.481*	0.594**	0.527*	0.628**	0.579**	0.463
	Turn velocity (mean)—ankle	23	−0.226	0.325	0.274	0.415*	0.371	0.236
	Turn velocity (std)—ankle	23	−0.520*	0.490*	0.533*	0.498*	0.501*	0.377
Mobility (balance)	Sway distance left–right	23	0.568*	−0.532**	−0.478*	−0.610**	−0.599**	−0.271
	Sway distance anterior–posterior	23	0.503*	−0.489*	−0.457*	−0.587**	−0.550**	−0.237
	Sway displacement left–right	23	0.513*	−0.518*	−0.378	−0.514*	−0.440*	−0.376
	Sway displacement anterior–posterior	23	0.184	−0.120	−0.021	−0.257	−0.110	−0.021
Overall activity	Heart rate variability	16	−0.519*	0.488*	0.434	0.391	0.677**	0.241
Fatigue	Mean PVT delay—Total	23	0.242	−0.486*	−0.510*	−0.422*	−0.542**	−0.429
	Mean PVT delay—1 challenge	23	0.360	−0.362	−0.347	−0.335	−0.291	−0.310
	Mean PVT delay—3 challenges	23	0.291	−0.456*	−0.489*	−0.432*	−0.360	−0.418
	Mean PVT delay—5 challenges	23	0.348	−0.508*	−0.542*	−0.489*	−0.431*	−0.469
	Mean PVT delay—7 challenges	23	0.304	−0.498*	−0.525*	−0.410	−0.508*	−0.412

EDSS expanded disability status scale, MSFC-4 multiple sclerosis functional composite-4, LCVA low contrast visual acuity test

*p- and q-values 0.05, **p- and q-values 0.01