Table 3.
Previous and ongoing clinical trials
| Bacterial strain | Phase | Cancer type | n | References |
|---|---|---|---|---|
| S. Typhimurium VNP20009 | I | Metastatic melanoma; metastatic renal cell carcinoma | 25 | 159 |
| S. Typhimurium VNP20009 | I | Melanoma | 4 | 53 |
| S. Typhimurium VNP20009 expressing TAPET-CD (cytosine deaminase) | I | Head and neck or esophageal adenocarcinoma | 3 | 54 |
| S. Typhimurium VNP20009 | I | Patients with advanced or metastatic solid tumors | Not provided | http://www.clinicaltrials.gov/ct2/show/NCT00004216 |
| S. Typhimurium VNP20009 | I | Unspecified adult solid tumors | Not provided | https://www.clinicaltrials.gov/ct2/show/NCT00006254 |
| S. Typhimurium VNP20009 | I | Neoplasm or neoplasm metastatic tumors | 45 | http://www.clinicaltrials.gov/ct2/show/NCT00004988 |
| S. Typhimurium expressing human IL-2 | I | Liver cancer | 22 | https://www.clinicaltrials.gov/ct2/show/NCT01099631 |
| S. Typhimurium Ty21a VXM01 | I | Pancreatic cancer | 26 | 172 |
| Clostridium novyi-NT | I | Colorectal cancer | 2 | https://www.clinicaltrials.gov/ct2/show/NCT00358397 |
| Clostridium novyi-NT | I | Solid tumor malignancies | 5 | https://www.clinicaltrials.gov/ct2/show/NCT01118819 |
| Clostridium novyi-NT | I | Solid tumor malignancies | 24 | https://www.clinicaltrials.gov/ct2/show/NCT01924689 |
| Clostridium novyi-NT | Ib | Refractory advanced solid tumors | 18- recruiting | https://clinicaltrials.gov/ct2/show/NCT03435952 |
| Listeria monocytogenes | II | Metastatic pancreatic tumors | 90 | 173 |
| Listeria monocytogenes | II | Cervical cancer | 109 | 174 |
| Listeria monocytogenes | III | Cervical cancer | 450- recruiting | https://clinicaltrials.gov/ct2/show/record/NCT02853604 |