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. 2019 Dec 11;9:18829. doi: 10.1038/s41598-019-55100-2

Figure 2.

Figure 2

Changes in the expression of miR-146a in PBMCs from chronic HIV-1 infected patients. Quantitative PCR detection of miR-146a relative levels in PBMCs from early stage (n = 96) and chronic stage (n = 109) individuals of HIV-1 infected patients. (a) miR-146a relative levels in CD4+ T cell counts <350 cells/µl group (n = 77) were compared with CD4+ T cell counts ≥350 cells/µl group (n = 32) from chronic stage individuals or healthy controls (n = 35) (b), U6 was used as an endogenous control. (c) Correlation between miR-146a and CD4+ T cell counts was analyzed using Spearman’s correlation test (n = 109). Values of the correlative coefficient (r) and p are shown. (d) Quantitative PCR for miR-146a relative levels in the groups of HBV–HIV+ (n = 33), HBV + HIV+ (n = 21); HCV–HIV+ (n = 33), HCV + HIV+ (n = 22); TB–HIV+ (n = 33), TB + HIV+ (n = 20); CMV–HIV+ (n = 33), CMV + HIV+ (n = 24) and uninfected individuals (n = 35). *p < 0.05, **p < 0.01, ***p < 0.001. ns, not significant.