Table 1.

List of major cytokines that are produced by T. gondii infection and the effect of each cytokine.

Cytokines	Producing cell	Effects	Refs.
IL-12	CD8α+or CD8αr CDCs	Activate and stimulate proliferation of NK cells, CD4 T cells and CD8 T cells	6–8
	Macrophages
	pDCs		9,10,25
IFN-γ	ILC1s	Induce cell-autonomous immune responses	19,20,24
	CD4 T cells	iNOS induction	26–28
	CD8 T cells	IDO production	29,32
	NK cells
	T-bet+Foxp3-Th1 cells
TNF-α	Macrophages DCs	Induce other inflammatory proteins	22–24
IL-1β	Macrophages	Induce other inflammatory proteins	22–24
IL-10	Ly6ChighCCR2+ monocytes	Suppress inflammation to prevent toxoplasma encephalitis	43,47,48
	B cells	Suppress hyper inflammation	49–51
	T-bet+Foxp3-Th1 cells		52–54
IL-27	Myeloid cells	Required for resistance to chronic toxoplasmic encephalitis	45,46,55
		Induce CXCR3, T-bet, Blimp1 and IL-10 expression
		Inhibit Th17 development
IL-33	Damaged cells	Induce CCL2 expression (proinflammatory)	56
	Tissue injury	Induce IL-10 production by M2 macrophages (anti-inflammatory)