Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 11;9:18870. doi: 10.1038/s41598-019-54716-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effect of tridecaptin M on the outer and cytoplasmic membranes of various pathogens. (a) NPN assay to determine the disruption of outer membrane. M₁ showed positive results in all the strains, despite of its high MIC in P3R strain, A. baumannii and P. aeruginosa. M₁₁ demonstrated greater uptake of NPN, compared to M₁, even a lower concentration. (b) Membrane depolarization assay with DiSC3(5). Similar results were obtained for M₁, as observed in the NPN assay. This data suggests that the resistance to tridecaptin M in these strains (excluding ATCC 700603) may be due to efflux pumps or some other mechanisms. Both the experiments were conducted in triplicate, with three biological repeats.