Table 3.
Strain | Intrinsic Activity; MIC (µg/ml) | MIC (µg/ml) of Tri-M in the presence of EPIs | FICI | ||||||
---|---|---|---|---|---|---|---|---|---|
PAβN | CCCP | CCCP | |||||||
Tri-M | PAβN | CCCP | 1/4th MIC | 1/8th MIC | 1/4th MIC | 1/8th MIC | 1/4th MIC | 1/8th MIC | |
A. baumannii ATCC 19606 | 64 | 64 | 64 | 64 | 64 | 4 | 8 | 0.31 | 0.25 |
P. aeruginosa ATCC 27853 | 256 | 64 | 64 | 256 | 256 | 256 | 256 | — | — |
K. pneumoniae ATCC 700603 | 2 | 256 | 128 | 2 | 2 | 2 | 2 | — | — |
K. pneumoniae P3R (Tri-M Resistant) | 64 | 256 | 128 | 64 | 64 | 64 | 64 | — | — |
K. pneumoniae GMCH 13 | 8 | 256 | 32 | 8 | 8 | 4 | 8 | 0.75 | — |
K. pneumoniae GMCH 15 | 16 | 256 | 64 | 16 | 16 | 4 | 8 | 0.5 | 0.62 |
Tri-M= Tridecaptin M (or M1).