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. 2019 Dec 11;9:18830. doi: 10.1038/s41598-019-55027-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Candidate gene pool induces S-phase re-entry in cultured adult mouse cardiomyocytes. (a) Lineage-traced cardiomyocytes transduced with a pool of candidate genes show S-phase activity via EdU labeling of in situ fixed cardiomyocytes. (b) Quantification of S-phase induction by pooled candidate genes compared to known cardiomyocyte cell cycle regulators p38i/FGF-1 and constitutively active Yap (caYap). Ad-GFP was used as a control for Adenovirus treatment. Negative control is no virus. (c) A subpool comprising genes 1–17 contains a candidate gene that is capable of activation of EdU incorporation in adult cardiomyocytes. (d) Identification of E2F2 that is sufficient to induce adult cardiomyocyte S-phase entry. Error bars represent standard deviation of mean from greater than or equal to 3 independent experiments. Asterisk indicates significance p < 0.05 compared to negative control. Scale bars, 100 μm.