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. 2019 Dec 11;9:18896. doi: 10.1038/s41598-019-55383-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of zoledronic acid (ZOL) and dexamethasone (DEX) on gingival fibroblast and keratinocyte functions. (a) Gingival fibroblasts and keratinocytes were cultured for 72 h with Dulbecco’s modified Eagle medium (DMEM) (control) or with 10 µM ZOL, DEX and ZOL(+)/DEX(+). Proliferation was analyzed with XTT. Cells cultured in 10 µM ZOL or 10 µM ZOL(+)/DEX(+) showed decreased viability after 48 and 72 h (P ≤ 0.03 vs. DMEM), whereas cells in the other groups demonstrated increased cell viability throughout the experiment. (b) Confluence of the wound was monitored every hour and analyzed using the IncuCyte software. GF treated with ZOL or ZOL(+)/DEX(+) showed delayed wound closure (P ≤ 0.004), whereas keratinocytes were less affected by the drugs. Experiments repeated tree times in triplicates.