Table 1.
Organizational characteristics and substrates of human organic anion transporters[4,14,21,45,63,151,152,153]
| Protein name | Alias | Chromosome localization | Distribution location | Substrates (Km value) |
| OAT1 | SLC22A6 | 11q13.1 | Kidney, brain, liver, stomach, pancreas | P-aminohippurate (PAH; 5 μmol), prostaglandin E2 (PGE2; 0.97 μmol), α-ketoglutaric acid, captopril, methotrexate |
| OAT2 | SLC22A7 | 6p21.1 | Liver, kidney, embryonic liver and kidney | PAH, PGE2 (0.71 μmol), estrone-3-sulfate (E3S), α-ketoglutaric acid (17.8 μmol), cGMP, succinic acid, paclitaxel (0.14 μmol), dehydroepiandrosterone (DHEA) sulfate, methotrexate, diclofenac, acyclovir, penciclovir, theophylline (12.6 μmol), erythromycin (18.5 μmol), salicylate (88.8 μmol) |
| OAT3 | SLC22A8 | 11q11.7 | Kidney, brain, liver, skeletal muscle, adrenal gland | PAH (87 μmol), PGE2 (0.34 μmol), E3S (3 μmol), zidovudine, cimetidine, bumetanide, ciprofloxacin, benzylpenicillin, pravastatin, methotrexate, bile acids, amino acids, MTX (11 μmol) |
| OAT4 | SLC22A11 | 11q12.3 | Kidney, placenta, adrenal gland | Urate, PGE2 (0.15 μmol), E3S (1 μmol), PAH, olmesartan, methotrexate, bumetanide |
| OAT5 | SLC22A10 | 11q12.3 | Liver | Unknown |
| OAT6 | SLC22A20 | 11q13.1 | Olfactory mucosa | E3S, PAH, PGE2, ibuprofen, ochratoxin A (OTA) |
| OAT7 | SLC22A9 | 11q12.3 | Liver | E3S, DHEA, sulfate, butyrate |
| OAT8 | UST6 | 11q12.3 | Liver | Unknown |
| OAT9 | SLC22A27 | Unknown | ||
| OAT10 | SLC22A13 | 3p22.2 | Kidney, brain, heart, colon | Lactate, nicotinate, succinate, glutathione urate |
| URAT1 | SLC22A12 | 11q13.1 | Kidney, vascular smooth muscle cells, liver, lung | Urea, chloride |
| S22AO | SLC22A24 | 11q12.3 | Kidney | Unknown |
| OCTL2 | SLC22A14 | 3p22.2 | Testis, kidney | Unknown |