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. 2019 Oct 30;142(12):3834–3851. doi: 10.1093/brain/awz331

Figure 1.

Figure 1

Dexamethasone blocks LPS/IFNγ and IL-1-induced IL-1 expression in primary BMDMs and microglia. Primary murine BMDMs (A) and microglia (B) were cultured using modifications of previously established protocols. Il1 expression in BMDMs (n = 4) (C) and microglia (n = 4) (D) following stimulation with LPS and IFNγ. Intracellular (n = 5) and secreted (n = 7) IL-1β protein levels in BMDMs (E) as well as intracellular (n = 6) and secreted (n = 8) IL-1β protein levels in microglia (F) following stimulation with LPS and IFNγ. IL-1α (G) and IL-1β (H) stimulation of BMDMs (n = 4). IL-1α (I) and IL-1β (J) stimulation of microglia (n = 4). One-way ANOVA, ns = not significant. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. MG = microglia.