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. 2019 Oct 30;142(12):3834–3851. doi: 10.1093/brain/awz331

Figure 8.

Figure 8

Genetic and pharmacological inhibition of IL-1 signalling have no impact on radiotherapy efficacy. (A) A schematic illustration of the irradiation of tumour-bearing Ntv-a (n = 13) and Ntv-a/Il1a/b−/− (n = 9) mice with the associated survival curves. (B) A schematic illustration of the treatment of tumour-bearing mice with vehicle (n = 10), gallium nitrate (n = 10), vehicle plus radiation (n = 10), or gallium nitrate plus radiation (n = 11) with the associated survival curves. Mantel-Cox (MC) and Gehan-Breslow-Wilcoxon (GBW) tests, ns = not significant. *P < 0.05, **P < 0.01, ****P < 0.0001. RCAS = replication-competent avian sarcoma-leukosis virus long terminal repeat with splice acceptor.