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. 2019 Dec 9;13(2):dmm040840. doi: 10.1242/dmm.040840

Fig. 4.

Fig. 4.

Awake extracellular spontaneous firing properties of Purkinje cells in mdx and control mice. (A) Schematic showing the recording approach. (B) Schematic illustrating the electrode placement for targeting the Purkinje cells. (C) Example raw voltage trace from a control Purkinje cell, with complex spikes indicated by green asterisks. (D) As in C, for mdx mice. (E) Average simple spike waveform for the cell shown in C. (F) Average complex spike waveform for the cell in C. (G,H) Simple spike and complex spike waveforms for the mdx cell shown in D. (I) Mean simple spike firing rate (y-axis) was significantly lower in mdx mice (red) compared to controls (blue). No statistically significant difference in mean CV (x-axis) was found. (J) Complex spikes in mdx mice have significantly lower firing variability compared to those in controls, but firing rates do not differ between the genotypes. Circles are individual data points; crosses represent mean±s.e.m. n=24 cells of each genotype, N=4 mice of each genotype. Please refer to Table S1 for a list of the statistical tests used in this figure.