Table 1.
Patients, tumor and treatment characteristics, stratified by tumor regression grade (TRG).
| Total N = 94 (%) |
TRG 1–2 N = 42 (%) |
TRG 3–5 N = 52 (%) |
P-value |
|
|---|---|---|---|---|
| Gender | ||||
| Male | 71 (76) | 28 (67) | 43 (83) | 0.07 |
| Female | 23 (25) | 14 (33) | 9 (17) | |
| Median age (years)[range] | 64 [25–82] | 64 [39–74] | 65 [25–82] | 0.69 |
| Weight loss at presentation | ||||
| None | 29 (31) | 18 (43) | 11 (21) | 0.06 |
| ≤10% | 42 (45) | 14 (33) | 28 (54) | |
| ˃10% | 23 (25) | 10 (24) | 13 (25) | |
| Alcohol consumption | ||||
| None or stopped | 28 (30) | 14 (33) | 14 (27) | 0.78 |
| Yes | 64 (68) | 27 (64) | 37 (71) | |
| Unknown | 2 (2) | 1 (2) | 1 (2) | |
| Smoking | ||||
| Never or stopped | 57 (61) | 25 (60) | 32 (62) | 0.63 |
| Yes | 36 (38) | 17 (41) | 19 (37) | |
| Unknown | 1 (1) | 0 (0) | 1 (2) | |
| Tumor location | ||||
| GEJ | 11 (12) | 3 (7) | 8 (15) | 0.46 |
| Middle | 9 (10) | 4 (10) | 5 (10) | |
| Low | 74 (79) | 35 (83) | 39 (75) | |
| Median length tumora(cm) [range] | 5 [1–11] | 5 [2–11] | 6 [1–10] | 0.53 |
| Histology | ||||
| Adenocarcinoma | 75 (80) | 32 (76) | 43 (83) | 0.44 |
| Squamous cell carcinoma | 19 (20) | 10 (24) | 9 (17) | |
| Cycles of chemotherapy | ||||
| <5 cycles | 13 (14) | 4 (10) | 9 (17) | 0.28 |
| 5 cycles | 81 (86) | 38 (91) | 43 (83) | |
| Median time interval between nCRT and surgery (days)[range] | 44 [25–85] | 43 [25–58] | 47 [31–85] | 0.12 |
| cT status | ||||
| cT2 | 16 (17) | 7 (20) | 9 (6) | 0.84 |
| cT3 | 72 (77) | 33 (74) | 39 (89) | |
| cTx | 6 (6) | 2 (7) | 4 (6) | |
| cN status | ||||
| cN0 | 23 (25) | 8 (19) | 15 (29) | 0.48 |
| cN1 | 42 (45) | 19 (45) | 23 (44) | |
| cN2 | 28 (30) | 14 (33) | 14 (27) | |
| cN3 | 1 (1) | 1 (2) | 0 (0) | |
| Differentiation grade | ||||
| Well/Moderate | 44 (47) | 20 (48) | 24 (47) | 0.98 |
| Poor | 50 (53) | 22 (52) | 28 (53) |
Abbreviations: GEJ: Gastro-esophageal junction.
a
Tumor length was determined by endoscopy. If tumor length by endoscopy was not reported, tumor length on CT scan was used instead.