Table 3.
Uni- and multivariable logistic regression analyses for TRG group 3–5.
| Univariable analysis |
Multivariable analysis |
|||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | AOR | 95% CI | P-value | |
| Gender | ||||||
| Male | Ref | |||||
| Female | 2.39 | 0.91–6.26 | 0.08 | |||
| Age (years) | 0.99 | 0.95–1.04 | 0.85 | |||
| Weight loss at presentation | ||||||
| None | Ref | |||||
| ≤10% | 0.31 | 0.11–0.82 | 0.02 | |||
| ˃10% | 0.47 | 0.15–1.43 | 0.18 | |||
| Alcohol consumption | ||||||
| None or stopped | Ref | |||||
| Yes | 0.73 | 0.30–1.78 | 0.49 | |||
| Smoking | ||||||
| Never or stopped | Ref | |||||
| Yes | 1.15 | 0.50–2.65 | 0.75 | |||
| Tumor location | ||||||
| GEJ | Ref | |||||
| Middle | 2.13 | 0.33–13.81 | 0.43 | |||
| Low | 2.39 | 0.59–9.74 | 0.22 | |||
| Length tumor (cm) | 0.97 | 0.81–1.17 | 0.78 | |||
| Histology | ||||||
| Adenocarcinoma | Ref | |||||
| Squamous cell carcinoma | 1.49 | 0.54–4.10 | 0.44 | |||
| Cycles of chemotherapy | ||||||
| <5 cycles | Ref | |||||
| 5 cycles | 1.99 | 0.57–6.98 | 0.28 | |||
| cT status | ||||||
| cT2 | Ref | |||||
| cT3 | 1.05 | 0.35–3.09 | 0.93 | |||
| cN status | ||||||
| cN0 | Ref | |||||
| cN+ | 1.72 | 0.65–4.57 | 0.28 | |||
| Differentiation grade | ||||||
| Well/Moderate | Ref | |||||
| Poor | 0.94 | 0.42–2.13 | 0.89 | |||
| Tumor-stroma ratio | ||||||
| Stroma-low | Ref | Ref | ||||
| Stroma-high | 3.50 | 1.06–11.61 | 0.04 | 3.57 | 1.03–12.31 | 0.04 |
Abbreviations: OR: Odds ratio; CI: Confidence interval; TRG: Tumor regression grade; GEJ: Gastro-esophageal junction; AOR: Adjusted odds ratio.