Fig. 2.

Identification of experimentally validated regulatory variants using variation-scan. A) Correlation of the Massively Parallel Reporter Assays (MPRA) p-value of the mRNA/DNA ratio of positive variants and the variation-scan weight difference for the MPRA variants with significant change. B) Receiver Operating Characteristic (ROC) curve comparing the performance when aiming to classify MPRA experimentally analyzed variants using variation-scan (turquoise), DeepSea (purple), deltaSVM (green), and a negative control which consists of permuted motifs scored with variation-scan (red). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)