Table 1.
List of potential single biomarkers for early detection of ovarian cancer.
| Biomarker | Sensitivity | Specificity | Methods performed | References |
|---|---|---|---|---|
| CA-125 | 92% | 80% | Electrochemilluminescence (ECLIA) technique | Lycke et al., (2018) |
| HE4 | 71.19 % | 85.0% | Clinical chemistry and immunochemistry | Zhang et al., (2019) |
| Osteopontin | 7.6% | 98% | ELISA | Moore et al., (2008) |
| VEGF | 74% | 71% | ELISA | Cooper et al., (2002) |
| KLK6 | 21%–26% | 95% | Immunoassay | Diamandis et al., (2003) |
| IL-6 | 84.1% | 86% | LabMAP assays | Gorelik et al., (2005) |
| IL-8 | 65.5% | 98% | LapMAP technology | Lokshin et al., (2006a) |
| Transthyretin | 47% | 95% | Singleplex Luminex bead assays | Cramer et al., (2011) |
| Prostasin | 51.4% | 94% | Enzyme-linked immunosorbent assay | Mok et al., (2001) |
| SMRP | 15.4% | 98% | MESOMARK™ Assay | Moore et al., (2008) |