Fig. 2.

Heat-maps of the 2D square domain showing the initial state of a simulated cell. The six key proteins (active/inactive Rho, active/inactive Rac and phosphorylated/unphosphorylated paxillin) were considered, while setting the remaining proteins to steady state. The simulated cell is a $40\times 40$ square lattice with an integer number of Rho, Rac and paxillin molecules residing in each lattice square. Heat-maps of the initial number of these proteins per lattice square, colour-coded according to the colour-bar to the right of each panel, show the spatially-uniform initial condition of our simulations. Simulations were initiated from a state with a lower level of inactive/active Rac/Rho and phosphorylated paxillin compared to active/inactive Rac/Rho and unphosphorylated paxillin (i.e. near the uninduced steady state).