Figure 8.

linc00174 Combined with miR-138-5p or miR-150-5p Enhanced the Anti-tumor Effect of Dox; Alternatively, It Further Enhanced the Feedback Loop

(A) The apoptosis of U87 cells was significantly increased by co-transfection of linc00174 and miR-138-5p or miR-150-5p treated with doxorubicin (Dox) (10 μM). Data represent mean ± SD (n = 3, each). *p < 0.05 versus control group; ^#p < 0.05 versus Dox group; ^@@p < 0.01 versus linc00174(−)+miR-138-5p(+) group; ^$$p < 0.01 versus linc00174(−)+miR-150-5p(+) group; ^&&p < 0.01 versus miR-138-5p(+) +miR-150-5p(+) group. (B) Cartoon of the mechanisms of the linc00174/miR-138-5p/miR-150-5p/FOSL2 feedback loop regulating permeability of BTB.