Table 2.
Top 30 significantly up-regulated genes in the keratinocytes treated with PM2.5.
| Associated Gene Name | log2.Fold change. | pvalue | padjue | Description |
|---|---|---|---|---|
| CXCL1 | 3.3047 | 1.37E-06 | 0.00045496 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| CYP1A1 | 2.7319 | 4.01E-11 | 2.83E-08 | cytochrome P450 family 1 subfamily A member 1 |
| S100A8 | 2.6565 | 5.16E-07 | 0.0001883 | S100 calcium binding protein A8 |
| EIF3CL | 2.4628 | 7.74E-09 | 3.76E-06 | eukaryotic translation initiation factor 3 subunit C-like |
| S100A9 | 2.319 | 1.79E-09 | 9.31E-07 | S100 calcium binding protein A9 |
| HMGCS1 | 1.8909 | 4.51E-42 | 1.64E-38 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 |
| IL1RN | 1.689 | 6.44E-10 | 3.71E-07 | interleukin 1 receptor antagonist |
| INSIG1 | 1.5304 | 9.01E-11 | 5.98E-08 | insulin induced gene 1 |
| KRT6B | 1.3754 | 4.66E-12 | 3.51E-09 | keratin 6B, type II |
| TNFAIP3 | 1.3361 | 8.01E-19 | 1.17E-15 | TNF alpha induced protein 3 |
| SERPINB2 | 1.3277 | 2.99E-16 | 3.63E-13 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| SOD2 | 1.3093 | 3.74E-10 | 2.27E-07 | superoxide dismutase 2, mitochondrial |
| NFKBIA | 1.2489 | 9.67E-08 | 3.92E-05 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| TXNRD1 | 1.2116 | 2.89E-15 | 3.28E-12 | thioredoxin reductase 1 |
| TACSTD2 | 1.1573 | 3.00E-15 | 3.28E-12 | tumor-associated calcium signal transducer 2 |
| HBEGF | 1.1016 | 1.27E-09 | 6.94E-07 | heparin-binding EGF-like growth factor |
| MSMO1 | 1.0632 | 3.23E-20 | 5.04E-17 | methylsterol monooxygenase 1 |
| FASN | 1.0064 | 1.30E-89 | 2.83E-85 | fatty acid synthase |
| ACLY | 0.99489 | 6.19E-24 | 1.04E-20 | ATP citrate lyase |
| ALDH1A3 | 0.98715 | 2.55E-12 | 2.15E-09 | aldehyde dehydrogenase 1 family member A3 |
| SQLE | 0.9585 | 6.93E-11 | 4.74E-08 | squalene epoxidase |
| ACSS2 | 0.95247 | 2.72E-10 | 1.75E-07 | acyl-CoA synthetase short-chain family member 2 |
| FGFBP1 | 0.95138 | 7.90E-40 | 2.47E-36 | fibroblast growth factor binding protein 1 |
| FTL | 0.93974 | 8.68E-19 | 1.19E-15 | ferritin, light polypeptide |
| BHLHE40 | 0.89669 | 9.37E-07 | 0.00031543 | basic helix-loop-helix family member e40 |
| KRT19 | 0.87714 | 1.83E-08 | 8.70E-06 | keratin 19, type I |
| HMGCR | 0.8467 | 2.49E-08 | 1.13E-05 | 3-hydroxy-3-methylglutaryl-CoA reductase |
| IL1B | 0.83678 | 2.44E-06 | 0.00073037 | interleukin 1 beta |
| TFPI2 | 0.8355 | 3.93E-10 | 2.33E-07 | tissue factor pathway inhibitor 2 |
| INHBA | 0.82203 | 3.44E-06 | 0.00099125 | inhibin beta A |