Table 2.

Univariable and multivariable analyses for local control and overall survival.

	Local control			Overall survival
	HR	95% CI	P-value	HR	95% CI	P-value
Univariate analysis
Group dose (≤100 Gy vs. >100 Gy)	4.20	1.47 – 11.98	0.007	2.67	1.34 – 5.33	0.005
Age at treatment (continues)	1.00	0.95 – 1.05	0.99	1.00	0.97 – 1.04	0.80
Primary tumor (CRC vs. other)	2.09	0.48 – 9.17	0.33	0.76	0.37 – 1.55	0.45
Extrahepatic disease (present vs. absent)	0.91	0.32 – 2.57	0.85	1.16	0.58 – 2.30	0.67
Prior chemotherapy (Yes vs. no)	1.49	0.55 – 4.02	0.43	1.04	0.54 – 1.99	0.91
GTV (cm3)	1.02	1.01 – 1.03	0.001	1.02	1.01 – 1.02	<0.001
BED98% (Gy) per 10 Gy	0.90	0.78 – 0.95	0.013	0.90	0.84 – 0.99	<0.001
BED2% (Gy) per 10 Gy	0.94	0.85 – 0.97	0.029	0.95	0.91 – 0.99	0.012
Relative near-min. PTV dose	0.99	0.97 – 1.01	0.20	0.99	0.90 – 1.01	0.27
Infield recurrencea				3.55	1.77 – 7.13	<0.001
Multivariate analysis
Group dose (≤100 Gy vs. >100 Gy)	3.61	1.25 – 10.40	0.017	2.38	1.16 – 4.90	0.005
Age at treatment (continues)
Primary tumor (CRC vs. other)
Extra hepatic disease (present vs. absent)
Prior chemotherapy (Yes vs. no)
GTV (cm3)	1.01	1.00 – 1.02	0.005	1.01	1.01 – 1.02	<0.0001
BED98% (Gy) per 10 Gy
BED2% (Gy) per 10 Gy
Relative near-min. PTV dose

Abbreviations: HR = hazard ratio. CI = Confidence Interval. CRC = colorectal cancer. GTV = Gross Tumor Volume. BED = Biologically Effective Dose. BED_98% = near-minimum BED. BED_2% = near-maximum BED. PTV = Planning Target Volume.

^aInfield recurrence as a time dependent variable.