Fig. 4.

Correlations between eigenvector centrality changes in CBS and disease severity. Positive and negative Spearman's correlations between FTLD-CDR, as proxy for disease severity, and eigenvector centrality in the significant clusters from the ECM CBS>controls comparison. The more severe the disease, the lower the interconnectedness in the right temporal/insular cortex, and the higher the interconnectedness in left caudate nucleus, suggesting proportional connectivity changes with disease severity and, potentially, brain compensation. MNI coordinates for the clusters are reported on the side of each scatterplot. Dotted lines represent 95% confidence intervals. Abbreviations: CBS corticobasal syndrome; ECM eigenvector centrality mapping; FTLD-CDR frontotemporal lobar degeneration – clinical dementia rating scale.