Fig. 6.

External validation of SVM model based on T1-MRI. Histogram plots display the function value distributions derived from the SVM based on T1-MRI data. Dashed lines represent function values for controls (blue) and patients (red) based on whole-brain SVM analysis. The continuous red line represents the distribution of function values for the new independent cohort of 39 CBS patients. The use of meta-analytically derived regions of interests leads to improved generalization of the SVM classifier to new data. Color bars show the proportion of correctly classified CBS patients from the new cohort for both whole brain and meta-analysis guided models. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)