Bechdolf 2011.
Methods | Allocation: randomised.
Design: single‐centre.
Duration: 6 months.
Setting: Inpatient, some of the treatment could be as outpatient. Location: Cologne, Germany. |
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Participants | Diagnosis: ICD‐10 schizophrenia or schizoaffective disorder (n = 50, 83.3%) or substance‐induced psychosis (n = 10) with substance abuse or dependence. N = 60. Age: mean 31.5 years. Sex: 43 M, 17 F. Ethnicity: not reported. Inclusion criteria: German speaking and excluded if they were close to discharge. | |
Interventions | 1. Psychosocial intervention: MI (4 individual sessions of 50 minutes each given as an inpatient) plus routine care. N = 30. 2. Standard care: routine care plus 4 sessions of non‐specific supportive sessions (Supportive Therapy, ST). N = 30. | |
Outcomes | Leaving the study early: lost to evaluation (3 and 6 months). Unable to use Mental state: PANSS (no means or SDs reported). Global state: GAF (no means or SDs reported). Substance use: ASI alcohol, cannabis consumption (skewed data). Service use: relapse (hospitalisations) (not reported). |
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Notes | All analyses were performed by intention‐to‐treat conditions. Text was translated from German to English by internal translators. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Stratified for gender and SUD, single and multiple. Sequence generation not stated. |
Allocation concealment (selection bias) | Unclear risk | Researcher not involved in the study generated sequence. Insufficient information to permit judgement. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Clinician‐/participant‐mediated and participants and personnel not blinded. It is not possible to blind a psychosocial intervention. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Raters blinded so detection bias was rated as low. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Lost to follow‐up: 25% (15/60) 6 months. Missing data have been imputed using appropriate methods (LOCF), but these can still have unclear risk effects. |
Selective reporting (reporting bias) | Unclear risk | Rating of mental state not fully reported (numerical data not provided for PANSS, GAF) both secondary outcomes reported as not significantly different between groups over time. |
Other bias | Low risk | None according to authors. |