Bonsack 2011.
Methods | Allocation: randomised. Design: single‐centre. Duration: 12 months (6 months post treatment). Setting: inpatient and outpatient. Location: Lausanne Switzerland. |
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Participants | Diagnosis: DSM‐IV for schizophrenia, schizoaffective, schizotypal and brief psychotic disorder (n = 57, 92%) and cannabis misuse, 82% (n = 50) met criteria for cannabis dependence. N = 62. Age: mean 26.4 years (range 18‐35 years). Sex: 54 M, 8 F. Ethnicity: not stated. Inclusion criteria: current cannabis use (current alcohol or other drugs excluded) and good command of French. |
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Interventions |
1. Psychosocial intervention: MI (individual sessions and optional group sessions for up to 6 months). N = 30. 2. Standard care: TAU which included case management, early intervention and mobile team when needed. N = 32. |
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Outcomes | Leaving the study early: lost to treatment, lost to evaluation. Substance use: change in cannabis use from baseline. Mental state: PANSS (total, positive, negative symptoms). Global state: Global Assessment of functioning (GAF) Social functioning: Social and Occupational Social Functioning Scale (SOFAS) Service use: Hospital readmissions (12 months). Unable to use Substance use: Cannabis and alcohol use (ASI) (skewed data). |
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Notes | Authors have kindly provided further data. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated, blocks of 8. |
Allocation concealment (selection bias) | Unclear risk | Numbered sealed envelopes held by administration staff not involved with the research. Remains unclear whether envelopes were sequentially numbered, opaque and sealed. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Clinician‐/participant‐mediated and participants and personnel not blinded. It is not possible to blind a psychosocial intervention. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Raters were blinded so detection risk rated as low. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Lost to follow‐up: 13% (8/62) 1 year. Used ITT and replaced missing values with LOCF. Missing values balanced across treatments, however can still have unclear risk with imputations. |
Selective reporting (reporting bias) | Unclear risk | Reports fully all outcomes of interest (means, SD and n) mentioned in the Methods. No protocol. |
Other bias | Low risk | No evidence of other bias occurring. |