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. 2019 Dec 12;2019(12):CD001088. doi: 10.1002/14651858.CD001088.pub4

Bonsack 2011.

Methods Allocation: randomised.
Design: single‐centre.
Duration: 12 months (6 months post treatment).
Setting: inpatient and outpatient.
Location: Lausanne Switzerland.
Participants Diagnosis: DSM‐IV for schizophrenia, schizoaffective, schizotypal and brief psychotic disorder (n = 57, 92%) and cannabis misuse, 82% (n = 50) met criteria for cannabis dependence.
N = 62.
Age: mean 26.4 years (range 18‐35 years).
Sex: 54 M, 8 F.
Ethnicity: not stated.
Inclusion criteria: current cannabis use (current alcohol or other drugs excluded) and good command of French.
Interventions 1. Psychosocial intervention: MI (individual sessions and optional group sessions for up to 6 months). N = 30.
2. Standard care: TAU which included case management, early intervention and mobile team when needed. N = 32.
Outcomes Leaving the study early: lost to treatment, lost to evaluation.
Substance use: change in cannabis use from baseline.
Mental state: PANSS (total, positive, negative symptoms).
Global state: Global Assessment of functioning (GAF)
 Social functioning: Social and Occupational Social Functioning Scale (SOFAS)
Service use: Hospital readmissions (12 months).
Unable to use
Substance use: Cannabis and alcohol use (ASI) (skewed data).
Notes Authors have kindly provided further data.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated, blocks of 8.
Allocation concealment (selection bias) Unclear risk Numbered sealed envelopes held by administration staff not involved with the research. Remains unclear whether envelopes were sequentially numbered, opaque and sealed.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Clinician‐/participant‐mediated and participants and personnel not blinded. It is not possible to blind a psychosocial intervention.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Raters were blinded so detection risk rated as low.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Lost to follow‐up: 13% (8/62) 1 year. Used ITT and replaced missing values with LOCF. Missing values balanced across treatments, however can still have unclear risk with imputations.
Selective reporting (reporting bias) Unclear risk Reports fully all outcomes of interest (means, SD and n) mentioned in the Methods. No protocol.
Other bias Low risk No evidence of other bias occurring.