Figure 4.

DCs exist in peripheral tissues and entry into the lymphatic capillaries. The lymph nodes coordinate cell trafficking from two sources: the blood vessels, through which the majority of lymphocytes enter the lymph nodes, and the lymphatic vessels, which transport interstitial fluid, including DCs. The intensive defense provided by acquired immunity requires functional lymphatic organs. Lymphedema is a state in which the lymphatic conduits are impaired, expression of acquired immunity is impossible in the presence of lymphedema. DC, dendritic cell.