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Pyrexia induces caspase-3 cleavage in the OGD/R-injured cardiomyocytes (41 and 53 h) that was briefly attenuated by hypothermia (41 h). Undamaged normoxia control cardiomyocytes warmed to pyrexia also showed increased cleavage of caspase-3 (31 and 53 h). Data from 3 to 4 independent experiments is presented as mean ± SD. ∗p ≤ 0.05 and #p ≤ 0.05 as compared to normoxia control at 37°C (normalized to 1).
