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. 2019 Nov 23;2019:5820839. doi: 10.1155/2019/5820839

Figure 3.

Figure 3

Role of clathrin in the K+ channel degradation. (a) Clathrin levels in ECs treated with NNP or NP serum. Alteration in clathrin levels was not found between ECs treated with NNP or NP serum. (b) Clathrin levels in ECs treated with NP or PE serum. (c) Membrane clathrin levels in ECs treated with NP or PE serum. (d) Colocalization of clathrin and KCa3.1 was enhanced by PE serum or LPC. (e, f) Treatment with the clathrin inhibitor CPZ (2 μM) recovered KCa2.3 (e) or KCa3.1 (f) levels in the ECs treated with PE serum or LPC. Blots shown are representative of three to six experiments performed with three to six different cultures. Bar graphs represent the mean ± SEM. ∗P < 0.05, ∗∗P < 0.01.