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. 2019 Nov 23;2019:5820839. doi: 10.1155/2019/5820839

Figure 6.

Figure 6

Superoxide facilitates KCa2.3 or KCa3.1 endocytosis. (a) Elevated PM clathrin levels by PE serum were reduced by NOX4 inhibition using NOX4 siRNA. (b) Elevated Cav-1 levels by LPC were reduced by the antioxidants, tempol or tiron. (c) Elevated colocalization of KCa3.1 with Cav-1, clathrin, or Rab5c by LPC was reversed by the treatment with a pan-NOX inhibitor, VAS2870, or apocynin. (d, e) A superoxide donor, X/XO, elevated Cav-1 (d) or Rab5c (e) levels in a concentration-dependent manner. Blots shown are representative of three to four experiments performed with three to four different cultures. Bar graphs represent the mean ± SEM. ∗P < 0.05, ∗∗P < 0.01.