Figure 7.

A schematic model for altered redox state-induced modulation of PM-localized K_Ca2.3 and K_Ca3.1 in NP and PE. (a) PM-localized K_Ca2.3 and K_Ca3.1 are internalized via caveola- or clathrin-dependent processes and transported via a Rab5c- and EEA1-dependent process to early endosome. (b) Compared to NNP, the internalization and transport processes are delayed by H₂O₂ in NP, thus elevating PM-localized K_Ca2.3 and K_Ca3.1 levels. However, compared to NP, the internalization and transport processes are facilitated in PE, thus reducing PM-localized K_Ca2.3 and K_Ca3.1 levels.