Table 1.
Determination of IC50s of DOX and PTX in the combination of different concentrations of matrine. Cell viabilities were examined by WST-8 assay. IC50s were calculated. Reversal fold = IC50s for cells treated with matrine/IC50s for cells treated without matrine. Each value of IC50 represented as mean and SD of three independent experiments.
| Cells | Concentration of matrine (μmol/L) | IC50 of DOX (μmol/L) | Reversal fold |
|---|---|---|---|
| DOX | |||
| K562 | 0 | 2.75 ± 0.9 | |
| 200 | 2.38 ± 1.11 | 1.16 | |
| 300 | 2.77 ± 1.66 | 0.99 | |
| K562/ADR | 0 | 73.63 ± 2.37 | |
| 200 | 31.99 ± 4.31 | 2.3 | |
| 300 | 25.53 ± 1.28 | 2.88 | |
|
| |||
| PTX | IC50 of PTX (nmol/L) | ||
| K562 | 0 | 793 ± 149 | |
| 200 | 692 ± 77 | 1.15 | |
| 300 | 629 ± 37 | 1.26 | |
| K562/ADR | 0 | 7990 ± 561 | |
| 200 | 2789 ± 284 | 2.86 | |
| 300 | 2563 ± 196 | 3.12 | |