Fig. 4.

MalK structure with conserved motifs. A, Conserved motifs in the NBD of MalK. B, ATP-bound MalK structure (PDB: 1Q12) showing the subdomains and conserved motifs (in yellow) [78]. C, Open MalK dimer viewed from the side (PDB: 1Q1E). D, Open MalK dimer viewed from the top. The green and cyan spheres represent the V16 and R129 residues, respectively, that were used to monitor distance changes during closure of the dimer interface via EPR spectroscopy [99]. Closure of the MalK dimer is indicated by the dashed lines. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)