. Author manuscript; available in PMC: 2021 Feb 1.

Published in final edited form as: Mater Sci Eng C Mater Biol Appl. 2019 Oct 15;107:110267. doi: 10.1016/j.msec.2019.110267

Table 3.

Brief overview of the application of SNMs as scaffolds for bone tissue engineering.

	Matrix and scaffold	Preparation method	Examined cell line	Experi mental system	Advantages	Ref.
1	Polyhydroxybutyrate/poly(ε-caprolactone)/silica nanoparticles (PHB/PCL/SNPs)	Electrospinning, Sol-gel, Dispersion electrospinning	MG-63	In vitro	Enhanced viability, ALP activity	[33]
2	Bone forming peptide/SNPs	Covalent cross-linking	stem cells (hMSCs)	In vitro & In vivo	Enhanced cell adhesion, Survivability, Proliferation, Expansion and osteogenesis	[112]
3	Polyamidoamine/SNPs	Covalent cross-linking	mBM-MSC	In vitro & In vivo	Enhanced viability, biocompatibility, proliferation, Mechanical properties,	[114]
4	Poly(l-lactide acid)/silica nanoparticles (PLLA/SNPs)	Double sonication	Simulated body fluid (SBF)	In vitro	Enhanced mechanical properties,	[113]
5	Polylactic acid/silica nanoparticles (PLA/SNPs)	Melt mixing	MC3T3-E1	In vitro	Enhanced viability, proliferation and thermomechanical properties, Biodegradability	[111]
6	collagen-chitosan/SNPs	in situ gelation (Stober method)	Simulated body fluid (SBF)	In vitro	Enhanced viability, Low toxicity	[118]
7	Polycaprolactone Fibrous/SNPs	Electrostatic layer-by-layer self-assembly	hFOB 1.19	In vitro	Enhanced cell attachment, proliferation, and ALP	[58]