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Immunosuppressive functions of BM-MSCs. (a–b) The result of flow cytometry analysis showing the effect of three groups of BM-MSCs on the proliferation of PHA-activated PBMCs. PBMCs were cocultured with different ratios of BM-MSCs for 5 days. (c–d) The proportion of CD4+CD25high cells and CD4+CD25+Foxp3+ cells in the gate of CD4+ cells. All experiments were repeated at least three times. Data are presented as mean ± SD. ∗p < 0.05, ∗∗∗p < 0.001.
