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. 2019 Nov 21;2019:4686132. doi: 10.1155/2019/4686132

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Copyright © 2019 Huafang Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Analysis of transcriptome data in the control and overexpression BM-MSCs. (a) Heat map of DEG cluster. The expression levels of 435 genes change significantly in the overexpression group compared to the control group (p ≤ 0.001, (∣log2 FC∣) ≥ 1). Of these, 282 are commonly upregulated and 153 are commonly downregulated. (b) GO analysis of DEGs. Selected significant ontology terms are shown. The blue-colored columns indicate downregulation genes, while the orange-colored columns indicate upregulation genes. (c) GSEA analyses of gene expression profile in overexpression versus control cells. The normalized enrichment score (NES) and p values are shown. (d) Heat map of enriched DEGs between two groups is shown. APP_MHCII: antigen processing and presentation via MHC class II.