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. 2019 Dec 5;10:1258. doi: 10.3389/fneur.2019.01258

Figure 2.

Figure 2

Effects of intrastriatal memantine (MMT) infusion on levodopa-induced abnormal involuntary movements (AIMs) in dyskinetic mice. (A–D) Time-sequential changes in the AIM scores every 10 min over a period of 180 min after the last levodopa administration in mice with intrastriatal infusion of PBS (n = 7) or MMT (n = 7) at day 33 (B), day 36 (C), day 39 (D), and day 42 (E). (E) Total AIMs score in mice with intrastriatal infusion of PBS or MMT at days 33, 36, 39, and 42. Data are means ± SEM. A significant effect of the MMT infusion treatment is found [two-way ANOVA: F(group×dose)3,48 = 5.856, P = 0.0017]. Bonferroni post-hoc test: PBS day 33 vs. MMT day 33, not significant (N.S.); PBS day 36 vs. MMT day 36, N.S.; and PBS day 42 vs. MMT day 42, ***P < 0.001. Significant differences in the severity of AIMs at days 33, 36, and 42 are found (Bonferroni post-hoc test: MMT day 33 vs. MMT day 42, ##P < 0.01; MMT day 36 vs. MMT day 42, $$P < 0.01).