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. 2019 Dec 5;10:2815. doi: 10.3389/fimmu.2019.02815

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Copyright © 2019 Cao, Zhu, Qu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ERα expression in liver biopsies of PBC patients, HC and correlation with cytokines. (A–J) A significant immunohistochemical ERα positive expression in cholangiocytes of PBC patients (F) (n = 8, both cytoplasm and nucleus) (lower right panel), but negatively in HC (n = 5) (upper right panel) (original magnification, ×400). (G) ERα expression was higher in patients with PBC, **p < 0.01, compared with HC by a Mann–Whitney test. Data are represented as median with interquartile range. (H–J) Serum IL-6 (H), IL-8 (I), and TNF-α (J) level with the intensity of ERα in PBC patients. The p-values were determined by Spearman's rank correlation, P < 0.05 was considered significant. PBC, primary biliary cholangitis; HC: healthy control; IL-6, interleukin-6; IL-8, interleukin-8; TNF-α; tumor necrosis factor-alpha; ERα, estrogen receptor alpha.