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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Nat Struct Mol Biol. 2019 Nov 6;26(11):1044–1052. doi: 10.1038/s41594-019-0322-y

Extended Data Fig. 7. H50Q disrupts the wild-type rod polymorph preNAC protofilament interface.

Extended Data Fig. 7

a) Conformation of H50Q Protofilament A K45 and H50Q. b) Interaction of K45-H50-E57 in the wild-type rod polymorph protofilament interface. c) Hypothetical H50Q double protofilament using the preNAC of Protofilament A as a steric zipper interface. Notice that the H50Q mutation disfavors the protofilament interface due to steric clashes with E57. d) Hypothetical H50Q protofilament interface using preNAC of Protofilament B. Notice the steric clashes between H50Q and E57 at the hypothetical protofilament interface as well as clashes of other parts of the protofilament with Protofilament A.