Fig. 5.
Dapagliflozin slows MC38 colon adenocarcinoma tumor growth in an insulin-dependent manner. a, b Urine and plasma glucose concentrations. In all panels, mice were fasted for 5 h before studies were performed. c Plasma insulin concentrations. d, e Tumor glucose uptake and VPDH/VCS. f Tumor size. *P < 0.05, **P < 0.01, ***P < 0.001 vs. chow; +P < 0.05, ++P < 0.01, +++P < 0.001 vs. HFD + dapagliflozin. The color of the symbols indicates the group compared to the group designated by the symbols. In all panels, data are the mean ± S.E.M. of n = 5–6 per group, with groups compared by ANOVA with Bonferroni’s multiple comparisons test