Table 7.
Gene oncology (GO) clustering analysis of differentially expressed genes1 (|fold change| > 1.3 at a false discovery rate < 0.05) in relation to lipid metabolism, energy production and oxidation resistance (n = 4)
| GO terms | GO_ID | Differentially expressed genes (fold change) | P-value | Q-value |
|---|---|---|---|---|
| Biological Process | ||||
| Transport | GO:0006810 | FABP6 (0.58) | 0.010 | 0.010 |
| Regulation of intestinal cholesterol absorption | GO:0030300 | APOA1 (0.56), APOA4 (0.52) | < 0.001 | 0.004 |
| ATP synthesis coupled proton transport | GO:0015986 | ATP5H (0.72), ATP5I (0.68), ATP5L (0.66) | < 0.001 | 0.006 |
| Phospholipid efflux | GO:0033700 | APOA1 (0.56), APOA4 (0.52) | < 0.001 | 0.011 |
| Positive regulation of cholesterol esterification | GO:0010873 | APOA1 (0.56), APOA4 (0.52) | < 0.001 | 0.021 |
| Hydrogen peroxide catabolic process | GO:0042744 | PRDX1 (0.74), APOA4 (0.52) | < 0.001 | 0.035 |
| Reverse cholesterol transport | GO:0043691 | APOA1 (0.56), APOA4 (0.52) | < 0.001 | 0.035 |
| Removal of superoxide radicals | GO:0019430 | PRDX1 (0.74), APOA4 (0.52) | < 0.001 | 0.047 |
| Cellular Component | ||||
| Mitochondrial proton-transporting ATP synthase complex | GO:0000276 | ATP5H (0.72), ATP5I (0.68), ATP5L (0.66) | < 0.001 | < 0.001 |
| Very-low density lipoprotein particle | GO:0034361 | APOA1 (0.56), APOA4 (0.52) | 0.001 | 0.035 |
| Molecular Function | ||||
| Lipid binding | GO:0008289 | FABP1 (0.38), FABP2 (0.49), FABP3 (0.41) | 0.004 | 0.009 |
| Transporter activity | GO:0005215 | FABP6 (0.58) | 0.008 | 0.008 |
| Antioxidant activity | GO:0016209 | APOA4 (0.52), FABP1 (0.38) | 0.001 | 0.008 |
| Phosphatidylcholine-sterol O-acyltransferase activator activity | GO:0060228 | APOA1 (0.56), APOA4 (0.52) | < 0.001 | 0.002 |
| Glutathione transferase activity | GO:0004364 | GSTA3 (0.69), GSTM2 (0.59), GSTO1 (0.73) | < 0.001 | 0.005 |
| Hydrogen ion transmembrane transporter activity | GO:0015078 | ATP5H (0.72), ATP5I (0.68), ATP5L (0.66) | < 0.001 | 0.007 |
| Cholesterol transporter activity | GO:0017127 | APOA1 (0.56), APOA4 (0.52) | < 0.001 | 0.027 |
1FABP fatty acid-binding protein, APOA apolipoprotein A, ATP5H ATP synthase subunit d, ATP5I ATP synthase subunit e, ATP5J ATP synthase subunit f, ATP5L ATP synthase subunit g, PRDX1 peroxiredoxin-1, GSTA3 glutathione S-transferase alpha 3, GSTM2 glutathione S-transferase mu 2, GSTO1 glutathione S-transferase omega-1