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. 2019 Dec 12;18:182. doi: 10.1186/s12943-019-1114-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Chemotherapeutic drugs strikingly facilitate the intercellular transfer of ABCB1. A The representative confocal images show the promotion of VCR on the intercellular transfer of ABCB1. Red represents Cy3-ABCB1 and green is GFP. B-C The effect of VCR on the intercellular transfer of ABCB1 is determined by flow cytometry. D The representative confocal images show the DDP-increased intercellular transfer of ABCB1. E-F The effect of DDP on the intercellular transfer of ABCB1 is determined by flow cytometry. G-H Aq-MDR cells acquire moderate surface expression levels of ABCB1. I-J Aq-MDR cells express high level of ABCB1 protein, but not mRNA. GAPDH is used as an internal control. Data represent the mean transfer rate ± S.D. * = P < 0.05, ** = P < 0.01