Table 2.

Model performances of the best model based on electroencephalography features, mean arterial pressure and age, the best model including IMPACT features at admission and the IMPACT predictor independently, predicting poor outcome both as Extended Glasgow Outcome Scale (GOSE) 1–2 and GOSE 1–4. For both the internal validation within the training set and the validation set, the number of patients (N), area under the receiver operating characteristic curve (AUC) values with 50% confidence interval, and sensitivity and specificity at an optimal threshold are shown

Performance measures for the prediction model	Best model, 72 + 96 h		Best model, 72 + 96 h + IMPACT		IMPACT predictor
Poor outcome	GOSE 1–2	GOSE 1–4	GOSE 1–2	GOSE 1–4	GOSE 1–2	GOSE 1–4
Training set
N	30	25	29	25	38	30
AUC (50% CI)	0.88 (0.83–0.91)	0.66 (0.57–0.74)	0.94 (0.89–0.96)	0.61 (0.51–0.68)	0.74 (0.66–0.79)	0.67 (0.61–0.73)
Threshold	0.541	0.740	0.680	0.591	0.650	0.530
Sensitivity	0.92 (0.81–0.98)	0.71 (0.59–0.80)	0.75 (0.61–0.85)	0.76 (0.66–0.85)	0.65 (0.54–0.75)	0.63 (0.53–0.72)
Specificity	0.77 (0.66–0.85)	0.75 (0.57–0.88)	1.00 (0.92–1.00)	0.50 (0.33–0.67)	0.81 (0.72–0.88)	0.82 (0.67–0.91)
Validation set
N	14	14	14	14	19	19
AUC (50% CI)	0.75 (0.60–0.86)	0.73 (0.62–0.82)	0.81 (0.69–0.88)	0.76 (0.65–0.89)	0.84 (0.76–0.89)	0.87 (0.78–0.92)
Threshold	0.623	0.805	0.378	0.668	0.550	0.349
Sensitivity	0.83 (0.61–0.95)	0.78 (0.61–0.89)	1.00 (0.79–1.00)	0.89 (0.73–0.97)	0.88 (0.70–0.96)	1.00 (0.88–1.00)
Specificity	0.88 (0.70–0.96)	0.80 (0.55–0.94)	0.75 (0.57–0.88)	0.80 (0.55–0.94)	0.73 (0.58–0.84)	0.75 (0.57–0.88)

IMPACT International Mission for Prognosis And Clinical Trial Design, GOSE Extended Glasgow Outcome Scale, AUC area under the receiver operating characteristic curve, CI confidence interval

Performences of the best model referred to throughout the manuscript is shown in italic