Table 2.
Validated hits from hSSPN-EGFP screen reveal enrichment of calcium channel blockers
| Compound | Description |
|---|---|
| Felodipine | L-type Ca2 + channel blocker |
| GW5074 | cRaf1 kinase inhibitor |
| Isoproterenol | Sympathomimetic amine acting on β-adrenoceptors |
| Isradipine | L-type Ca2 + channel blocker |
| Lacidipine | L-type Ca2 + channel blocker |
| Nandrolone | Anabolic-androgenic steroid |
| Nilvadipine | L-type Ca2 + channel blocker |
The screen resulted in 13 initial hits, which were further validated with the hSSPN-EGFP reporter with an n = 24. The 7 validated hits included an overrepresented number of L-type calcium channel blockers