. 2019 Dec 12;14(12):e0226293. doi: 10.1371/journal.pone.0226293

Table 5. Multivariable analysis of the independent variables with the recent CD-4 T-cells progression over time, among HIV infected patients on ART from April, 2015 to January, 2019 in Tigray region, Northern Ethiopia (n = 19525).

Variables	Category	Adjusted IRR (95% CI)	P-value
Baseline CD4 T-cells count/mm³		1.0007 (1.00069, 1.00078)	0.000
Gender	Female	1 (Ref.)
Gender	Male	0.85 (0.83, 0.86)	0.000
Age category	15–19	1 (Ref.)
	20–24	0.84 (0.78, 0.89)	0.000
	25–29	0.79 (0.75, 0.84)	0.000
	30–34	0.80 (0.76, 0.85)	0.000
	35–39	0.77 (0.73, 0.82)	0.000
	40–44	0.76 (0.72, 0.80)	0.000
	45–49	0.75 (0.71, 0.79)	0.000
	50+	0.73 (0.69, 0.77)	0.000
Facility type	Clinic	1 (Ref.)
	Health center	0.94 (0.86, 1.03)	0.178
	Primary hospital	1.02 (0.93, 1.12)	0.656
	General hospital	1.12 (0.98, 1.22)	0.17
	Referral Hospital	1.00 (0.91, 1.10)	0.975
	Other	1.18 (1.07, 1.31)	0.001
A service provided at military health care facility	No	1 (Ref.)
A service provided at military health care facility	Yes	1.11 (1.06, 1.16)	0.000
WHO Stage	I	1 (Ref.)
	II	0.92 (0.89, 0.96)	0.000
	III	0.89 (0.84, 0.95)	0.000
	IV	1.00 (0.95, 1.04)	0.923
Adherence	Poor	1 (Ref.)
	Fair	0.98 (0.90, 1.06)	0.602
	Good	1.12 (1.04, 1.21)	0.002
Virological test reason	Routine first VL (6 Months or more on ART)	1 (Ref.)
	Routine annual VL test	1.01 (1.00, 1.03)	0.085
	Suspected ART failure clinical	0.69 (0.58, 0.81)	0.000
	Suspected ART failure immunological	0.55 (0.45, 0.66)	0.000
	Suspected ART failure initial VL	0.80 (0.77, 0.83)	0.000
	Not indicated in the form	0.96 (0.91, 1.02)	0.161
Regimen	1c (AZT-3TC-NVP)	1 (Ref.)
	1d (AZT-3TC-EFV)	1.00 (0.98, 1.03)	0.845
	1e (TDF-3TC-EFV)	0.92 (0.91, 0.94)	0.000
	1f (TDF + 3TC+ NVP)	0.99 (0.97, 1.02)	0.453
	1g (ABC + 3TC + EFV)	1.03 (0.82, 1.29)	0.817
	1h (ABC + 3TC NVP)	0.80 (0.57, 1.12)	0.19
	2a (ABC-ddl-LPV/R), 2c (TDF-ddl-LPV/R), 2d(TDF-ddl-NFV)& 2g (TDF-3TC-LPV/r)	0.73 (0.53, 1.01)	0.06
	2f (AZT-3TC-ATV/r)	0.65 (0.55, 0.76)	0.000
	2h (TDF-3TC-ATV/r)	0.71 (0.63, 0.81)	0.000
Treatment line	First line	1 (Ref.)
Treatment line	Second line	Omitted due to collinearity
Viral load suppression	No	1 (Ref.)
Viral load suppression	Yes	1.31 (1.28, 1.33)	0.000