Table 2. Characteristics of pre-TSS diagnostics and the long-term outcome of each patient.
| Pat. No. | Adenoma position in MRI | BIPSS | Adenoma position at TSS | Histology | Definitive treatment | Time of HC substitution from definitive treatment | Rec. post definitive treatment (yrs.) | Long-term outcome |
|---|---|---|---|---|---|---|---|---|
| 1 | R | - | No data | Adenoma | TSS + (BA after rec.) | From TSS1 to Rec (1 yr); after BA to now (9 yrs.) |
Yes (1.00) | Remission; Nelson’s syndrome (1.50 yrs. post BA) |
| 2 | ML* | - | L | Adenoma | TSS1+TSS2 | From TSS2 to latest FU (10.08 yrs.) | No | Remission |
| 3 | L | R | R | Adenoma | TSS1 | 0.83 yrs. | No | Remission |
| 4 | N | L | L | Adenoma | TSS1 | Until latest FU (13.50 yrs.) | No | Remission |
| 5 | R* | - | R | Adenoma | TSS1 | 2.00 yrs. | No | Remission |
| 6 | R* | - | R | Adenoma | TSS1 | Without HC | Rec suspicion | Rec. suspicion at latest FU |
| 7 | ML | ML | L | Adenoma | TSS1 | Until latest FU (11.80 yrs.) | No | Remission |
| 8 | R** | Yes *** | No data*** | Adenoma | TSS1+TSS2+XRT | From XRT to latest FU (23.83 yrs.) | No | Remission |
| 9 | L | ML | L | Adenoma | TSS1 | Until latest FU (9.50 yrs.) | No | Remission |
| 10 | N | - | No data*** | No data*** | TSS1 | 0.80 yrs. | No | Remission |
| 11 | L | - | No data | Adenoma | TSS1 | 2.17 yrs. | No | Remission |
| 12 | R* | - | R | Adenoma | TSS1 | Until latest FU (16.17 yrs.) | No | Remission |
| 13 | ML* | - | ML | Adenoma | TSS1 | Until latest FU (17.58 yrs.) | No | Remission |
| 14 | N | La | No data*** | No data*** | TSS1 | 3.25 yrs. | No | Remission |
| 15 | L* | - | L | Adenoma | TSS1 | 0.33 | Rec. suspicion | Rec. suspicion |
| 16 | ML* | - | R | Adenoma | TSS1 | 0.92 | No | Remission |
| 17 | N | - | No data*** | No data*** | TSS1 | 3.25 | No | Remission |
| 18 | R | - | ML | Adenoma | TSS1+TSS2 | No HC substitution | No | Remission |
| 19 | N (EPG) | +/- | R/ML | Adenoma | TSS1 | Until latest FU (7.92 yrs.) | No | Remission |
| 20 | N | R* | R | Adenoma | TSS1+TSS2+XRT+BA after Rec | 4.40 yrs. from XRT to Rec., after BA on HC | Yes (3.70 from XRT) | Remission |
| 21 | L | R | ML | Adenoma | TSS1+TSS2 | 1.75 from TSS1 to Rec. | Yes (1.75 yrs. from TSS1) | Death 1 month after TSS2 |
| 22 | ML* | - | No data | Adenoma | TSS1+TSS2*+BA (4 times) | 8.00 yrs. from TSS1 to Rec. | Yes (8.08 yrs. from TSS1) | Remission |
| 23 | N (NH FL) | - | No data*** | No data*** | - | - | - | Persistent disease (after TSS1 and XRT) |
| 24 | L* | - | No data | Adenoma | TSS1 | Until latest FU (24.33 yrs.) | No | Remission |
| 25 | L* | - | L | Adenoma | No data | No data | No data | No data |
| 26 | ML | **** | ML | Adenoma | TSS1 | Until latest FU (8.33 yrs.) | No | Remission |
| 27 | N | R | No data | Focal corticotroph cells hyperplasia | TSS1 | Until latest FU (2.33 yrs.) | No | Remission |
| 28 | N (NH FPL) | R | R/ML | No adenoma (normal pituitary gland) | TSS1 | 0.50 yr | No | Remission |
| 29 | R** | R | R | Adenoma | TSS1 | Until latest FU (0.67 yrs.) | No | Remission |
BIPSS—bilateral inferior petrosal sinus sampling
(-)—not performed
L—left-sided lateralization/adenoma position, R—right-sided lateralization/adenoma position; ML—no lateralization/ midline position
MRI—magnetic resonance imaging, N-normal imaging (no adenoma), EPG-enlarged pituitary gland, NH FL—non-homogeneous front lobe, NH FPL—non-homogeneous frontal and posterior lobe
*- outside CMHI
**- adenoma detected in the 2nd MRI
***- outside CMHI
****-unsuccessful—abnormal venous system—collateral vein of the right femoral vein and left jugular vein
+/-—ambiguous result
a but no data about lateralization